NPLinker
NP
Microbial natural products data mining by integrating genomics and metabolomics data
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NPLinker Web Application
This is the NPLinker web application, developed with Plotly Dash. It enables interactive visualization of NPLinker predictions and is designed to be run locally or in a containerized environment.
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- 1.Author(s): Paulo Wender P. Gomes, Talita Carla de Tralia Medeiros, Naydja Moralles Maimone, Tiago F. Leão, Luiz Alberto Beraldo de Moraes, Anelize BauermeisterPublished in Advances in Experimental Medicine and Biology, Microbial Natural Products Chemistry by Springer International Publishing in 2023, page: 225-24810.1007/978-3-031-41741-2_9
- 2.Author(s): Pieter M. M. van der Velden, Robert S. JansenPublished in Metabolomics by Springer International Publishing in 2023, page: 165-20810.1007/978-3-031-39094-4_6
- 1.Author(s): Buddha Bahadur Basnet, Zhen-Yi Zhou, Rajesh Basnet, Bin Wei, Hong WangPublished in Natural Products and Bioprospecting by Springer Science and Business Media LLC in 202610.1007/s13659-025-00556-1
- 2.Author(s): Karin Steffen, Manuel Rangel-Grimaldo, Thomas J. C. Sauters, David C. Rinker, Huzefa A. Raja, Tyler N. Graf, Adiyantara Gumilang, Olivia L. Riedling, Gustavo H. Goldman, Nicholas H. Oberlies, Antonis RokasPublished in Organic & Biomolecular Chemistry by Royal Society of Chemistry (RSC) in 2026, page: 1323-133810.1039/d5ob01965f
- 3.Author(s): Karla Alexa Pentón, Yvonne Mast, Beatriz CámaraPublished in Essays in Biochemistry by Portland Press Ltd. in 202610.1042/ebc20250019
- 4.Author(s): Cunliang Geng, Giulia Crocioni, Helge Hecht, Arjan Draisma, Annette Lien, Laura Rosina Torres Ortega, Dora Ferreira, Pablo Lopez-Tarifa, Katherine R. Duncan, Marnix H. Medema, Justin J. J. van der HooftPublished in Journal of Open Source Software by The Open Journal in 2026, page: 952810.21105/joss.09528
- 5.Author(s): Benjamin Philmus, Nicole E. Avalon, Yousong Ding, Drew T. Doering, Alessandra S. Eustáquio, William H. Gerwick, Hendrik Luesch, Jimmy Orjala, Shaz Sutherland, Arnaud Taton, Daniel UdwaryPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2026, page: 286-30010.1039/d5np00016e
- 6.Author(s): Huali Xie, Jie Hu, Xiulan Zhao, Jianwei Chen, Xiaofeng Yue, Changhao Zhou, Jorge C. Navarro-Muñoz, Jun Jiang, Xiaoqian Tang, Fang Zhao, E. Anne Hatmaker, Antonis Rokas, Amelia E. Barber, Milton T. Drott, Nancy P. Keller, Qi Zhang, Justin J. J. van der Hooft, Marnix H. Medema, Peiwu LiPublished in Nature Communications by Springer Science and Business Media LLC in 202610.1038/s41467-026-70721-8
- 7.Author(s): Antonio LavecchiaPublished in 202610.1002/med.70098
- 8.Author(s): Micah Harris, Asher Paul, Edward KalkreuterPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 202610.1039/d6np00034g
- 9.Author(s): Judith Boldt, Christoph Porten, F. P. Jake Haeckl, Joachim J. Hug, Fabian Panter, Matthias Steglich, Joachim Wink, Jörg Overmann, Markus Göker, Daniel Krug, Rolf Müller, Ulrich NübelPublished in Microbial Biotechnology by Wiley in 202610.1111/1751-7915.70298
- 10.Author(s): Arjan Draisma, Catarina Loureiro, Nico L. L. Louwen, Satria A. Kautsar, Jorge C. Navarro-Muñoz, Drew T. Doering, Nigel J. Mouncey, Marnix H. MedemaPublished in Nature Communications by Springer Science and Business Media LLC in 202610.1038/s41467-026-68733-5
- 11.Author(s): Yipaerguli Paerhati, Alifeiye Aikebaier, Dilihuma Dilimulati, Alhar Baishan, Nazhakaiti Yusufujiang, Xiaoxiao Qiu, Yilixiati Wusiman, Wenting ZhouPublished in Pharmaceuticals by MDPI AG in 2026, page: 30110.3390/ph19020301
- 12.Author(s): Elena Del Pup, Charlotte Owen, Ziqiang Luo, Hannah E. Augustijn, Arjan Draisma, Guy Polturak, Satria A. Kautsar, Anne Osbourn, Justin J.J. van der Hooft, Marnix H. MedemaPublished in Journal of Molecular Biology by Elsevier BV in 2026, page: 16979810.1016/j.jmb.2026.169798
- 13.Author(s): Somayah J. Jarallah, Fahad A. Almughem, Nada K. Alhumaid, Nojoud AL Fayez, Ibrahim Alradwan, Khulud A. Alsulami, Essam A. Tawfik, Abdullah A. AlshehriPublished in International Journal of Pharmaceutics by Elsevier BV in 2025, page: 12578910.1016/j.ijpharm.2025.125789
- 14.Author(s): Mohammed Salim Dason, Davide Corà, Angela RePublished in mSystems by American Society for Microbiology in 202510.1128/msystems.00333-25
- 15.Author(s): Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber, Justin J. J. van der HooftPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2025, page: 982-101910.1039/d4np00039k
- 16.Author(s): Qilong Lai, Shuai Yao, Yuguo Zha, Haohong Zhang, Haobo Zhang, Ying Ye, Yonghui Zhang, Hong Bai, Kang NingPublished in Nucleic Acids Research by Oxford University Press (OUP) in 202510.1093/nar/gkaf305
- 17.Author(s): Kai Blin, Simon Shaw, Lisa Vader, Judit Szenei, Zachary L Reitz, Hannah E Augustijn, José D D Cediel-Becerra, Valérie de Crécy-Lagard, Robert A Koetsier, Sam E Williams, Pablo Cruz-Morales, Sopida Wongwas, Alejandro E Segurado Luchsinger, Friederike Biermann, Aleksandra Korenskaia, Mitja M Zdouc, David Meijer, Barbara R Terlouw, Justin J J van der Hooft, Nadine Ziemert, Eric J N Helfrich, Joleen Masschelein, Christophe Corre, Marc G Chevrette, Gilles P van Wezel, Marnix H Medema, Tilmann WeberPublished in Nucleic Acids Research by Oxford University Press (OUP) in 2025, page: W32-W3810.1093/nar/gkaf334
- 18.Author(s): Kavin Raja M, Subathra Devi CPublished in Molecular Biology Reports by Springer Science and Business Media LLC in 202510.1007/s11033-025-10797-5
- 19.Author(s): Buddha Bahadur Basnet, Zhen-Yi Zhou, Bin Wei, Hong WangPublished in Critical Reviews in Biotechnology by Informa UK Limited in 2025, page: 1527-155810.1080/07388551.2025.2478094
- 20.Author(s): Abdelrahman M. Sedeek, Mariam Hassan, Tarek R. Elsayed, Mohamed A. RamadanPublished in Archives of Microbiology by Springer Science and Business Media LLC in 202510.1007/s00203-025-04570-2
- 21.Author(s): Roberth Riggs Rondilla, RuAngelie Edrada-EbelPublished in Critical Reviews in Microbiology by Informa UK Limited in 2025, page: 323-33810.1080/1040841x.2025.2556931
- 22.Author(s): Carolina Cano-Prieto, Agustina Undabarrena, Ana Calheiros de Carvalho, Jay D. Keasling, Pablo Cruz-MoralesPublished in Annual Review of Biochemistry by Annual Reviews in 2024, page: 411-44510.1146/annurev-biochem-032620-104731
- 23.Author(s): Douglas Sweeney, Alexander Bogdanov, Alexander B. Chase, Gabriel Castro-Falcón, Alma Trinidad-Javier, Samira Dahesh, Victor Nizet, Paul R. JensenPublished in Journal of Natural Products by American Chemical Society (ACS) in 2024, page: 2768-277810.1021/acs.jnatprod.4c00934
- 24.Author(s): Mahnoor Zulfiqar, Vinay Singh, Christoph Steinbeck, Maria SorokinaPublished in Critical Reviews in Microbiology by Informa UK Limited in 2024, page: 1053-109210.1080/1040841x.2024.2306465
- 25.Author(s): Scarlet Ferrinho, Helen Connaris, Nigel J. Mouncey, Rebecca J.M. GossPublished in Water Research by Elsevier BV in 2024, page: 12149210.1016/j.watres.2024.121492
- 26.Author(s): Colleen E. Yancey, Lauren Hart, Sierra Hefferan, Osama G. Mohamed, Sean A. Newmister, Ashootosh Tripathi, David H. Sherman, Gregory J. DickPublished in mSystems by American Society for Microbiology in 202410.1128/msystems.00334-24
- 27.Author(s): Felicia C. Wolters, Elena Del Pup, Kumar Saurabh Singh, Klaas Bouwmeester, M. Eric Schranz, Justin J.J. van der Hooft, Marnix H. MedemaPublished in Current Opinion in Plant Biology by Elsevier BV in 2024, page: 10265710.1016/j.pbi.2024.102657
- 28.Author(s): Maximilian J. Helf, Kathrin Buntin, Andrej Klančar, Michael Rust, Frank Petersen, Dominik Pistorius, Eric Weber, Joanne Wong, Philipp KrastelPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2024, page: 1824-183410.1039/d4np00022f
- 29.Author(s): Martin Baunach, Arthur Guljamow, María Miguel-Gordo, Elke DittmannPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2024, page: 347-36910.1039/d3np00045a
- 30.Author(s): Allison S. Walker, Jon ClardyPublished in Biochemistry by American Chemical Society (ACS) in 2024, page: 2705-271310.1021/acs.biochem.4c00464
- 31.Author(s): Donghui Yan, Muqing Zhou, Abhinav Adduri, Yihao Zhuang, Mustafa Guler, Sitong Liu, Hyonyoung Shin, Torin Kovach, Gloria Oh, Xiao Liu, Yuting Deng, Xiaofeng Wang, Liu Cao, David H. Sherman, Pamela J. Schultz, Roland D. Kersten, Jason A. Clement, Ashootosh Tripathi, Bahar Behsaz, Hosein MohimaniPublished in Nature Communications by Springer Science and Business Media LLC in 202410.1038/s41467-024-49587-1
- 32.Author(s): Joris J. R. Louwen, Marnix H. Medema, Justin J. J. van der HooftPublished in Microbiome by Springer Science and Business Media LLC in 202310.1186/s40168-022-01444-3
- 33.Author(s): Francesc Puig-Castellví, Romina Pacheco-Tapia, Maxime Deslande, Manyi Jia, Petros Andrikopoulos, Kanta Chechi, Amélie Bonnefond, Philippe Froguel, Marc-Emmanuel DumasPublished in TrAC Trends in Analytical Chemistry by Elsevier BV in 2023, page: 11724810.1016/j.trac.2023.117248
- 34.Author(s): Michael W. Mullowney, Katherine R. Duncan, Somayah S. Elsayed, Neha Garg, Justin J. J. van der Hooft, Nathaniel I. Martin, David Meijer, Barbara R. Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric J. N. Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A. van Santen, Maria Sorokina, Marcy J. Balunas, Mehdi A. Beniddir, Doris A. van Bergeijk, Laura M. Carroll, Chase M. Clark, Djork-Arné Clevert, Chris A. Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, Willem Jespers, Olga V. Kalinina, Satria A. Kautsar, Hyunwoo Kim, Tiago F. Leao, Joleen Masschelein, Evan R. Rees, Raphael Reher, Daniel Reker, Philippe Schwaller, Marwin Segler, Michael A. Skinnider, Allison S. Walker, Egon L. Willighagen, Barbara Zdrazil, Nadine Ziemert, Rebecca J. M. Goss, Pierre Guyomard, Andrea Volkamer, William H. Gerwick, Hyun Uk Kim, Rolf Müller, Gilles P. van Wezel, Gerard J. P. van Westen, Anna K. H. Hirsch, Roger G. Linington, Serina L. Robinson, Marnix H. MedemaPublished in Nature Reviews Drug Discovery by Springer Science and Business Media LLC in 2023, page: 895-91610.1038/s41573-023-00774-7
- 35.Author(s): Joris J. R. Louwen, Satria A. Kautsar, Sven van der Burg, Marnix H. Medema, Justin J. J. van der HooftPublished in PLOS Computational Biology by Public Library of Science (PLoS) in 2023, page: e101046210.1371/journal.pcbi.1010462
- 36.Author(s): Susana P. Gaudêncio, Engin Bayram, Lada Lukić Bilela, Mercedes Cueto, Ana R. Díaz-Marrero, Berat Z. Haznedaroglu, Carlos Jimenez, Manolis Mandalakis, Florbela Pereira, Fernando Reyes, Deniz TasdemirPublished in Marine Drugs by MDPI AG in 2023, page: 30810.3390/md21050308
- 37.Author(s): Lindsay K. Caesar, Fatma A. Butun, Matthew T. Robey, Navid J. Ayon, Raveena Gupta, David Dainko, Jin Woo Bok, Grant Nickles, Robert J. Stankey, Don Johnson, David Mead, Kristof B. Cank, Cody E. Earp, Huzefa A. Raja, Nicholas H. Oberlies, Nancy P. Keller, Neil L. KelleherPublished in Nature Chemical Biology by Springer Science and Business Media LLC in 2023, page: 846-85410.1038/s41589-023-01276-8
- 38.Author(s): Mitja M. Zdouc, Justin J.J. van der Hooft, Marnix H. MedemaPublished in Trends in Pharmacological Sciences by Elsevier BV in 2023, page: 532-54110.1016/j.tips.2023.06.004
- 39.Author(s): Xingran Kou, Peiqin Shi, Chukun Gao, Peihua Ma, Huadong Xing, Qinfei Ke, Dachuan ZhangPublished in Journal of Agricultural and Food Chemistry by American Chemical Society (ACS) in 2023, page: 6789-680210.1021/acs.jafc.3c00909
- 40.Author(s): Samuel Goldman, Jeremy Wohlwend, Martin Stražar, Guy Haroush, Ramnik J. Xavier, Connor W. ColeyPublished in Nature Machine Intelligence by Springer Science and Business Media LLC in 2023, page: 965-97910.1038/s42256-023-00708-3
- 41.Author(s): Bartosz Jan Bartmanski, Miguel Rocha, Maria Zimmermann-KogadeevaPublished in Current Opinion in Chemical Biology by Elsevier BV in 2023, page: 10232410.1016/j.cbpa.2023.102324
- 42.Author(s): Tiago F Leão, Mingxun Wang, Ricardo da Silva, Alexey Gurevich, Anelize Bauermeister, Paulo Wender P Gomes, Asker Brejnrod, Evgenia Glukhov, Allegra T Aron, Joris J R Louwen, Hyun Woo Kim, Raphael Reher, Marli F Fiore, Justin J J van der Hooft, Lena Gerwick, William H Gerwick, Nuno Bandeira, Pieter C DorresteinPublished in PNAS Nexus by Oxford University Press (OUP) in 202210.1093/pnasnexus/pgac257
- 43.Author(s): Zeling Xu, Tae-Jin Park, Huiluo CaoPublished in Critical Reviews in Microbiology by Informa UK Limited in 2022, page: 18-3710.1080/1040841x.2022.2036099
- 44.Author(s): Amrisha Bhosle, Ya Wang, Eric A Franzosa, Curtis HuttenhowerPublished in Current Opinion in Microbiology by Elsevier BV in 2022, page: 10219510.1016/j.mib.2022.102195
- 45.Author(s): Morgan Anne Feeney, Jake Terry Newitt, Emily Addington, Lis Algora-Gallardo, Craig Allan, Lucas Balis, Anna S. Birke, Laia Castaño-Espriu, Louise K. Charkoudian, Rebecca Devine, Damien Gayrard, Jacob Hamilton, Oliver Hennrich, Paul A. Hoskisson, Molly Keith-Baker, Joshua G. Klein, Worarat Kruasuwan, David R. Mark, Yvonne Mast, Rebecca E. McHugh, Thomas C. McLean, Elmira Mohit, John T. Munnoch, Jordan Murray, Katie Noble, Hiroshi Otani, Jonathan Parra, Camila F. Pereira, Louisa Perry, Linamaria Pintor-Escobar, Leighton Pritchard, Samuel M. M. Prudence, Alicia H. Russell, Jana K. Schniete, Ryan F. Seipke, Nelly Sélem-Mojica, Agustina Undabarrena, Kristiina Vind, Gilles P. van Wezel, Barrie Wilkinson, Sarah F. Worsley, Katherine R. Duncan, Lorena T. Fernández-Martínez, Matthew I. HutchingsPublished in Microbial Genomics by Microbiology Society in 202210.1099/mgen.0.000824
- 46.Author(s): Anelize Bauermeister, Helena Mannochio-Russo, Letícia V. Costa-Lotufo, Alan K. Jarmusch, Pieter C. DorresteinPublished in Nature Reviews Microbiology by Springer Science and Business Media LLC in 2021, page: 143-16010.1038/s41579-021-00621-9
- 47.Author(s): Lindsay K. Caesar, Rana Montaser, Nancy P. Keller, Neil L. KelleherPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2021, page: 2041-206510.1039/d1np00036e
- 48.Author(s): Agustina Undabarrena, Camila F. Pereira, Worarat Kruasuwan, Jonathan Parra, Nelly Sélem-Mojica, Kristiina Vind, Jana K. SchnietePublished in Microbiology by Microbiology Society in 202110.1099/mic.0.001084
- 49.Author(s): Mehdi A. Beniddir, Kyo Bin Kang, Grégory Genta-Jouve, Florian Huber, Simon Rogers, Justin J. J. van der HooftPublished in Natural Product Reports by Royal Society of Chemistry (RSC) in 2021, page: 1967-199310.1039/d1np00023c
- 50.Author(s): Max CrüsemannPublished in Marine Drugs by MDPI AG in 2021, page: 14210.3390/md19030142
- 1.Author(s): Arjan Draisma, Catarina Loureiro, Nico L.L. Louwen, Satria A. Kautsar, Jorge C. Navarro-Muñoz, Drew T. Doering, Nigel J. Mouncey, Marnix H. MedemaPublished by openRxiv in 202510.1101/2025.08.20.671210
- 2.Author(s): Douglas Sweeney, Alexander Bogdanov, Alexander B. Chase, Gabriel Castro-Falcón, Alma Trinidad-Javier, Samira Dahesh, Victor Nizet, Paul R. JensenPublished by openRxiv in 202410.1101/2024.10.29.620887
- 3.Author(s): Huali Xie, Jie Hu, Xiaofeng Yue, Fang Zhao, Jianwei Chen, Justin J.J. van der Hooft, Marnix Medema, Peiwu Li, Qi ZhangPublished by Springer Science and Business Media LLC in 202310.21203/rs.3.rs-2471999/v2
- 4.Author(s): Tymor Hamamsy, Meet Barot, James T. Morton, Martin Steinegger, Richard Bonneau, Kyunghyun ChoPublished by openRxiv in 202310.1101/2023.11.26.568742
- 5.Author(s): Huali Xie, Jie Hu, Xiaofeng Yue, Fang Zhao, Jianwei Chen, Justin J.J. van der Hooft, Marnix Medema, Peiwu Li, Qi ZhangPublished by Springer Science and Business Media LLC in 202310.21203/rs.3.rs-2471999/v1
- 6.Author(s): Joris J. R. Louwen, Marnix H. Medema, Justin J. J. van der HooftPublished by Springer Science and Business Media LLC in 202210.21203/rs.3.rs-1391827/v1
- 7.Author(s): Joris J.R. Louwen, Satria A. Kautsar, Sven van der Burg, Marnix H. Medema, Justin J.J. van der HooftPublished by openRxiv in 202210.1101/2022.08.05.502908
- 8.Author(s): Mitja M. Zdouc, Hannah E. Augustijn, Nataliia V. Machushynets, Lina M. Bayona, Sylvia Soldatou, Niek F. de Jonge, Sarah Casu, Marcel Jaspars, Gilles P. van Wezel, Marnix H. Medema, Justin J. J. van der HooftPublished by openRxiv in 202210.1101/2022.12.21.521422
- 9.Author(s): Tiago F. Leão, Mingxun Wang, Ricardo da Silva, Alexey Gurevich, Anelize Bauermeister, Paulo Wender P. Gomes, Asker Brejnrod, Evgenia Glukhov, Allegra T. Aron, Joris J. R. Louwen, Hyun Woo Kim, Raphael Reher, Marli F. Fiore, Justin J.J. van der Hooft, Lena Gerwick, William H. Gerwick, Nuno Bandeira, Pieter C. DorresteinPublished by openRxiv in 202110.1101/2021.10.05.463235
Contributors
GC
Giulia Crocioni
Netherlands eScience Center
SR
Simon Rogers
AR
Andrew Ramsay
KD
Katherine Duncan
Jv
Justin van
GH
Grímur Hjörleifsson
SS
Sylvia Soldatou
FH
Florian Huber
JW
Joe Wandy
RD
Ronan Daly
JL
Joris Louwen
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NPLinker
A community-supported workflow connecting microbial genes, and organisms to their molecular products
Updated 12 months ago
Finished