Folklore Clinical Variant Interpretation MCP

Folklore is Helena Bioinformatics' public, read-only Model Context Protocol (MCP) adapter for source-linked GRCh38 germline variant interpretation, ACMG/AMP decision support, and related biomedical literature discovery.

Agents can use the current scientific tool surface to:

• retrieve normalized public variant evidence with search_variant_evidence;
• discover variant-linked publications with search_variant_literature;
• retrieve source-linked publication records with get_publication_details;
• search the maintained literature corpus with search_literature_corpus.

Release 1.4.1 also retains the separate, non-scientific support_helena information helper.

Public access

• MCP endpoint: https://api.helena.bio/folklore/v1/mcp
• Product site: https://folklore.helena.bio
• Integration guide: https://folklore.helena.bio/integrations
• Source code: https://github.com/helena-bioinformatics/folklore-mcp
• Official MCP Registry identity: io.github.helena-bioinformatics/folklore

The public adapter is licensed under Apache-2.0 and does not require an account, API key, or OAuth.

Scope and safety

The accepted scientific input boundary is GRCh38 germline nuclear SNVs and simple indels shorter than 50 bp. The service accepts no patient, phenotype, family, segregation, private-case, credential, or uploaded private content. Results are evidence-discovery and decision-support outputs; they require qualified professional review and must not be treated as a diagnosis or treatment recommendation.