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FEDMix

Fusible evolutionary deep neural network mixture learning from distributed data for robust medical...

Automated Medical Image Analysis (MIA) has the potential to truly innovate clinical practice by offering solutions to routine, yet key tasks, such as segmentation (i.e., delineating organs). Especially with recent advances in machine learning (ML), in particular in Deep Neural Networks (DNNs) that have led to an explosive growth of successful MIA studies reported in academic literature, the time appears right for such innovations to find widespread real-world uptake.

Yet, labor-intensive manual performance of these tasks is still often daily clinical practice. In this proposal, we integrate DNNs with other state-of-the-art computational intelligence techniques, in particular evolutionary algorithms (EAs), to overcome 2 key obstacles in moving toward widespread clinical uptake of computationally intelligent MIA techniques: 1) observer variation in the definition of a ground truth, and 2) image quality variation due to different acquisition protocols and scanners at different institutes.

In particular, we design and develop efficient-computing-compatible implementations of mixtures of DNNs, the results of which can be fused with results learned from other  data sets (i.e., from different institutes).

To maintain sufficient focus while doing so, we consider an elementary, but key MIA task: segmentation. Moreover, by means of an application in radiotherapy treatment planning, in collaboration with the Academic Medical Center in Amsterdam, we validate the newly developed technology on real-world patient data within the runtime of the proposed project.

Participating organisations

CWI
Netherlands eScience Center

Team

AM
Adriënne Mendrik
eScience Coordinator
Netherlands eScience Center
Christiaan Meijer
Christiaan Meijer
eScience Research Engineer
Netherlands eScience Center
PB
Peter Bosman
Principal investigator
CWI

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