polymorphic-gompertzian

This repository contains the code used to evaluate the polymorphic Gompertzian model of cancer against in vitro and in vivo data on non-small cell lung cancer (NSCLC). The study assesses whether the model can reproduce observed tumor growth dynamics in heterogeneous cancer populations consisting of treatment-sensitive and treatment-resistant cells.

The repository contains Jupyter notebooks for fitting the model to experimental cell-growth data and longitudinal tumor volume data from previously published clinical studies. The analyses include parameter estimation, goodness-of-fit assessment, and comparison with alternative cancer dynamics models. The underlying datasets are available from their original published sources and are not redistributed here.