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MUSICiAn

Data and code underlying the publication: MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis

5
contributors

Description

This repository consists of code to reproduce the results of the paper "MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis".

The code to reproduce the paper is shared at: https://github.com/joanagoncalveslab/MUSICiAn

No experimental data was collected as part of this project, this project only utilised previously publicly available datasets. Details on accessing this data are fully described in the Methods section; "Data and preprocessing", "Mutational outcome data".

Logo of MUSICiAn
Keywords
compositional data analysis
control-free
CRISPR
DNA damage response
DNA repair
isometric log-ratio transformation
mahalanobis distance
mutational spectra
outlier detection
License
  • GPL-3.0-only
</>Source code
Not specified

Contributors

CS
Colm Seale
JG
Joana Gonçalves
MT
Marcel Tijsterman
MB
Marco Barazas
RvS
Robin van Schendel

Member of community

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