SoftwareApplication
identifier: 10.1111/imr.12666
name: iReceptor Gateway
description: A Distributed Data Management System and Scientific Gateway for Mining Next Generation Sequence Data from Immune Responses.
description: # What is iReceptor? iReceptor is a data discovery platform that facilitates the curation, analysis and sharing of antibody/B-cell and T-cell receptor repertoires (Adaptive Immune Receptor Repertoire or AIRR-seq data) from multiple labs and institutions. We are committed to providing a platform for researchers to increase the value of their data through sharing with the community. This will greatly increase the amount of data available to answer complex questions about the adaptive immune response, accelerating the development of vaccines, therapeutic antibodies against autoimmune diseases, and cancer immunotherapies. Visit the COVID-19 page for a list of curated COVID-19 AIRR-seq studies. # Our Approach The iReceptor Gateway integrates large, distributed, AIRR-seq data repositories, following standards for sharing and interoperability developed by the Adaptive Immune Receptor Repertoire (AIRR) Community. The main goal of iReceptor is to connect this distributed network of AIRR-seq repositories into an AIRR Data Commons, allowing queries across multiple projects, labs, and institutions. Present functionalities include: * Search for repertoires satisfying certain metadata (e.g. find all AIRR-seq repertoires from ovarian cancer studies) * Search for all repertoires that contain specific CDR3 sequences * Search identified repertoires for sequences derived from particular V, D, and J genes and alleles * Download sequences from these repertoires in AIRR.tsv format, easily importable to other AIRR-seq analysis tools iReceptor is a member of the iReceptor Plus Consortium. This project will expand the analysis tools available on the Gateway, including for single cell or systems immunology approaches, and add security for iReceptor Plus repositories. Users of the iReceptor Gateway can search AIRR-seq data from studies on ovarian cancer, autoimmune diseases such as MS and SLE, and infectious diseases such as COVID-19 and HIV. Visit the iReceptor Studies page for a list of cur…
code repository: https://github.com/sfu-ireceptor/gateway
author: Person
  given name: Nishanth
  family name: Marthandan
  name: Nishanth Marthandan
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: Person
  given name: Bojan
  family name: Zimonja
  name: Bojan Zimonja
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: Person
  given name: Jerome
  family name: Jaglale
  name: Jerome Jaglale
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: Person
  given name: Yang
  family name: Zhou
  name: Yang Zhou
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: Person
  given name: Emily
  family name: Barr
  name: Emily Barr
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: https://orcid.org/0000-0001-8712-1566
author: Person
  given name: Frances M. W.
  family name: Breden
  name: Frances M. W. Breden
  affiliation: Organization
    name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada
author: Person
  given name: Scott
  family name: Christley
  name: Scott Christley
  affiliation: Organization
    name: Department of Clinical Sciences; University of Texas Southwestern Medical Center; Dallas TX USA
author: Person
  given name: Jamie K.
  family name: Scott
  name: Jamie K. Scott
  affiliation: Organization
    name: Deptartment of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby BC Canada
author: https://orcid.org/0000-0003-1617-8244
author: https://orcid.org/0000-0001-9762-6314
author: https://orcid.org/0000-0003-3888-6495
keywords: Immunology
keywords: iReceptor
keywords: immunogenomics
programming language: Blade
programming language: Dockerfile
programming language: HTML
programming language: MATLAB
programming language: PHP
programming language: Perl
programming language: Python
programming language: R
programming language: Shell
programming language: Vue
license:
  creative work: creativeWork
    name: LGPL-3.0-only

https://orcid.org/0000-0001-8712-1566
type: Person
given name: Nicole
family name: Knoetze
name: Nicole Knoetze
affiliation: Organization
  name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada

https://orcid.org/0000-0003-1617-8244
type: Person
given name: Lindsay G.
family name: Cowell
name: Lindsay G. Cowell
affiliation: Organization
  name: Department of Clinical Sciences; University of Texas Southwestern Medical Center; Dallas TX USA

https://orcid.org/0000-0001-9762-6314
type: Person
given name: Felix
family name: Breden
name: Felix Breden
role name: Principal Ivestingator
affiliation: Organization
  name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada

https://orcid.org/0000-0003-3888-6495
type: Person
given name: Brian D.
family name: Corrie
name: Brian D. Corrie
role name: Principal Investigator
affiliation: Organization
  name: The IRMACS Centre; Simon Fraser University; Burnaby BC Canada